Abstract #0303
In-Vivo Assessment of Multi-Component Relaxation of Articular Cartilage using mcRISE at 3.0T
Fang Liu 1 , Alexey Samsonov 1 , Pouria Mossahebi 2 , Rajeev Chaudhary 2 , Wally Block 1,2 , and Richard Kijowski 3
1
Department of Medical Physics, University of
Wisconsin-Madison, Madison, Wisconsin, United States,
2
Department
of Biomedical Engineering, University of
Wisconsin-Madison, Madison, Wisconsin, United States,
3
Department
of Radiology, University of Wisconsin-Madison,
Wisconsin, United States
A new technique named multi-component Relaxation Imaging
using Steady-state signal Evolution (mcRISE) was
proposed in this study to resolve unbiased and
magnetization transfer (MT) corrected multi-component T2
measures. Our technique introduces a macromolecular
proton pool in exchange with regular two component water
pools and uses a combined model aimed for providing more
robust and unbiased multi-component T2 values along with
additional quantitative MT parameters, which may provide
a new set of biomarkers for assessing the cartilage
extracellular matrix in-vivo.
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