Abstract #0289
Towards Improved Characterization of Brain Tumors by 23 Na-MR Neuroimaging at 7 Tesla
Armin Biller 1,2 , Jens Kleesiek 3 , Jan Oliver Neumann 3 , Felix Sahm 4 , Anne Dorothea Hertenstein 3 , and Armin Michael Nagel 5
1
Neuroradiology, University of Heidelberg,
Heidelberg, Badem-Wrttemberg, Germany,
2
Radiology,
German Cancer Research Center DKFZ, Heidelberg, Badem-Wrttemberg,
Germany,
3
University
of Heidelberg, Baden-Wrttemberg, Germany,
4
Neuropathology,
Baden-Wrttemberg, Germany,
5
Medical
Physics in Radiology, German Cancer Research Center DKFZ,
Baden-Wrttemberg, Germany
In this study we demonstrate a robust correlation
between the Ki-67 proliferation index of brain tumor
cells and the relaxation weighted
23
Na
contrasts (NaR and NaS). Both contrasts represent the
signal of ions with short relaxation times. The NaT
contrast, which reflects the tissue sodium
concentration, exhibited no association with
histopathology. Also, statistical analyses revealed no
correlation between the Ki-67 index and canonical
1
H-MRI
including T1w gadolinium enhanced, T2w and FLAIR
imaging. These results emphasize the added benefit of
23
Na-MRI
to conventional
1
H
imaging in neurooncology. Of note, in contrast to
1
H
neuroimaging in oncology
23
Na-MRI
requires no contrast media.
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