Abstract #0254
Discrete Wavelet Analysis of Longitudinal Resting State fMRI in Mild TBI Patients
Chandler Sours 1,2 , Haoxing Chen 3 , Steven Roys 1 , and Rao P. Gullapalli 1,2
1
Diagnostic Radiology and Nuclear Medicine,
University of Maryland School of Medicine, Baltimore,
Maryland, United States,
2
Magnetic
Resonance Research Center (MRRC), Baltimore, MD, United
States,
3
University
of Maryland School of Medicine, Baltimore, Maryland,
United States
We investigated the mechanisms of recovery following
mild traumatic brain injury (mTBI) using discrete
wavelet analysis of resting state fMRI and its
relationship with post concussive syndrome (PCS). Our
results demonstrate reduced strength of resting state
coherence within the Default Mode Network in mTBI with
PCS compared to those without PCS within multiple
frequency ranges. These findings stress the importance
of investigating resting state coherence using discrete
wavelet analysis: however, further research is needed
incorporating cardiac and respiratory monitoring as well
as a sliding window analysis to fully characterize the
dynamic properties of resting state coherence in mTBI
patients.
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