Abstract #0216
Multi-parametric assessment of vascular reactivity in peripheral artery disease
Erin K Englund 1 , Michael C Langham 2 , Thomas F Floyd 3 , Felix W Wehrli 2 , and Emile R Mohler III 4
1
Department of Bioengineering, University of
Pennsylvania, Philadelphia, PA, United States,
2
Department
of Radiology, University of Pennsylvania, Philadelphia,
PA, United States,
3
Department
of Anesthesiology, Stony Brook University, Stony Brook,
NY, United States,
4
Department
of Medicine, University of Pennsylvania, Philadelphia,
PA, United States
A comprehensive investigation of peripheral
microvascular function in patients with peripheral
artery disease (PAD) is presented. The rate of recovery
following induced ischemia is monitored by dynamic
acquisition with Perfusion, Intravascular Venous Oxygen
saturation, and T2* (PIVOT). Analysis of the association
between the ankle-brachial index (ABI), which is the
clinical mainstay of PAD detection and diagnosis, and
PIVOT-derived time-course metrics found significant
correlations between ABI and time to peak perfusion and
between ABI and time to peak T
2
*.
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