Abstract #0197
Anthranilic Acid Analogues as Uncommonly Shifted HYdrogen bonded (U SHY) diamagnetic CEST (diaCEST) MRI Contrast Agents based on the N-H exchange
Xiaolei Song 1,2 , Xing Yang 1 , Sangeeta Ray Banerjee 1 , Martin G Pomper 1,3 , and Michael T McMahon 1,2
1
The Russell H. Morgan Department of
Radiology and Radiological Science, The Johns Hopkins
University, Baltimore, Maryland, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States,
3
Institute
for Nanobiotechnology, The Johns Hopkins University,
Baltimore, Maryland, United States
Diamagnetic chemical exchange saturation transfer (diaCEST)
agents form a new class of imaging agents with unique
magnetic resonance properties. Here we present a series
of anthranilic acid analogues as examples of Uncommonly
Shifted HYdrogen-bonded (U SHY) diaCEST agents, which
produce significant and tunable contrast between 4.8 -
9.3 ppm from water. Five of these analogues, N-sulfonyl
anthranilic acids, are highly soluble and produce strong
CEST contrast. We also discovered that flufenamic acid,
a commercial non-steroidal anti-inflammatory drug,
displays CEST contrast at 4.8 ppm. These N-H U SHY
agents, with contrast insensitive to pH, are
complementary to existing diaCEST probes.
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