Abstract #0161
Functional connectivity of consolidated memory circuits in rabbit after trace eyeblink conditioning
Matthew P Schroeder 1 , Craig Weiss 1 , Daniel Procissi 2 , and John F Disterhoft 1
1
Physiology, Northwestern University,
Chicago, IL Illinois, United States,
2
Radiology,
Northwestern University, Chicago, IL Illinois, United
States
Memory acquisition initially depends on the hippocampus
but long-term memory resides in a distributed cortical
network. This study characterized functional
connectivity changes at sites mediating long-term
memory. New Zealand White rabbits underwent trace
eyeblink conditioning for ten days. Resting state scans
were acquired following each session in a 7T Bruker MRI.
Rabbits demonstrated greater hippocampal connectivity
with HVI cerebellum, perirhinal cortex and thalamus and
greater prefrontal connectivity with cholinergic basal
forebrain after conditioning. Connectivity gradually and
significantly changed as a result of learning a
forebrain-dependent task. Future studies may identify
additional regions showing connectivity changes as a
result of learning.
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