Abstract #0155
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is superior to T1rho-mapping in measuring cartilage sulphated glycosaminoglycan content: preliminary results of an in-vivo validation study using an ex-vivo reference standard for cartilage sulphated glycosaminoglycan content
Jasper van Tiel 1,2 , Gyula Kotek 1 , Max Reijman 2 , Pieter K. Bos 2 , Esther E. Bron 1,3 , Stefan Klein 1,3 , Jan A. Verhaar 2 , Gabriel P. Krestin 1 , Harrie Weinans 2,4 , and Edwin H. Oei 1
1
Radiology, Erasmus MC, University Medical
Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands,
2
Orthopedic
Surgery, Erasmus MC, University Medical Center
Rotterdam, Rotterdam, Zuid-Holland, Netherlands,
3
Medical
Informatics, Erasmus MC, University Medical Center
Rotterdam, Rotterdam, Zuid-Holland, Netherlands,
4
Orthopedic
Surgery, University Medical Center Utrecht, Utrecht,
Utrecht, Netherlands
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)
has become a standard to quantitatively measure
cartilage sulphated glycosaminoglycan (sGAG) content.
T1rho-mapping has been proposed as non-contrast-enhanced
alternative to dGEMRIC to also quantitatively measure
cartilage sGAG content. However, no thorough validation
studies comparing both techniques acquired in-vivo
against a tissue reference standard for sGAG have been
performed. Our preliminary results suggest that dGEMRIC
can accurately measure articular cartilage sGAG content,
whereas T1rho-mapping is not suitable for this purpose.
Therefore, despite the need to use a contrast agent, we
consider dGEMRIC to be superior to T1rho-mapping for
quantitatively measuring cartilage sGAG content.
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