Abstract #0142
Gadoxetate-enhanced MRI in rats with liver cirrhosis: comparison between functional liver parameters obtained with deconvolution analysis and compartmental models as markers of hepatocyte transporter expression
Cline Giraudeau 1 , Jean-Luc Daire 1 , Matthieu Lagadec 1 , Sabrina Doblas 1 , Catherine Pastor 2 , and Bernard Van Beers 1
1
INSERM Centre de Recherche Biomdicale
Bichat Beaujon,CRB3 U773, Universit Paris Diderot,
Sorbonne Paris Cit, Clichy, France,
2
Laboratoire
de Physiopathologie Hpatique et Imagerie
Molculaire,Hpitaux Universitaires de Genve, Geneva,
Switzerland
We have previously shown that the hepatic functional
parameters (hepatic extraction fraction (HEF) and mean
residence time (MRT)) obtained with deconvolution
analysis at gadoxetate-enhanced MRI correlate with the
expression of the oatp/mrp transporters in liver
cirrhosis. The aim of this study was to assess if a
multicompartmental model of hepatocytic transport gives
further insight into the expression of the oatp/mrp
transporters in liver cirrhosis. Both methods were
evaluated in normal and cirrhotic rats through
calculation of Akaike criteria and multiple regression
analysis. The superiority of a multicompartmental
relative to a deconvolution model remains here to be
proven.
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