Abstract #0136
Tract-Based Spatial Statistics Analysis of Diffusion Tensor Data in Very Preterm 7 year-olds
Claire E Kelly 1 , Deanne K Thompson 1,2 , Alexander Leemans 3 , Chris Adamson 1 , Jian Chen 1 , Terrie E Inder 4 , Jeanie LY Cheong 1,5 , Lex W Doyle 1,5 , and Peter J Anderson 1,6
1
Murdoch Childrens Research Institute,
Melbourne, VIC, Australia,
2
Florey
Institute of Neuroscience and Mental Health, Melbourne,
VIC, Australia,
3
Image Sciences Institute,
University Medical Center Utrecht, Utrecht, Netherlands,
4
Brigham
and Women's Hospital, Boston, MA, United States,
5
Royal
Women's Hospital, Melbourne, VIC, Australia,
6
Department
of Paediatrics, University of Melbourne, Melbourne, VIC,
Australia
Very preterm birth (VPT, <32 weeks gestation) increases
the risk of white matter injury. Tract-Based Spatial
Statistics (TBSS) provides a method for studying whole
brain white matter microstructure in VPT children. This
study analysed diffusion tensor data from 150 VPT
children and 35 term controls (born ≥37 weeks
gestation) at 7 years of age. There were regions of
higher diffusivity in the VPT children compared with
controls. Increasing brain abnormality scored on
neonatal MRI was associated with widespread lower
fractional anisotropy and higher diffusivity in VPT
children. TBSS provides a sensitive method for studying
white matter microstructure in VPT children.
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