Abstract #0101
On the use of the two-pool model to improve the accuracy of axon calibration
Alice Lebois 1 , Chun Hung Yeh 2 , Denis Le Bihan 3 , Ching-Po Lin 2 , and Cyril Poupon 3
1
NeuroSpin/CEA, Gif-Sur-Yvette, France,
2
National
Yang-Ming University, Taiwan,
3
NeuroSpin/CEA,
France
We here propose to study the reason for the systematic
overestimation of the smaller radius in available axon
diameter mapping techniques when a simple cylinder model
is used for the axon. Recent studies have introduced an
alternative model, assuming that water molecules close
to the axon membranes have a slow diffusivity while
those far from the membranes are characterized by a fast
diffusivity, yielding the two-pool cylinder model. This
study shows how attenuations from this model when
varying the thickness of the layer close to axonal
membranes can be similar to attenuations from the simple
cylinder model with higher radius for small radii.
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