Abstract #0055
Derivation and Evaluation of Amygdalo-Prefrontal Connections in Humans and Monkeys Using Diffusion Tractography
Longchuan Li 1 , Xiaoping Hu 2 , Jocelyne Bachevalier 3 , Warren Jones 1 , Sarah Shultz 1 , and Ami Klin 1
1
Department of Pediatrics, Marcus Autism
Center, Children's HealthCare of Atlanta, Emory
University, Atlanta, GA, United States,
2
Department
of Biomedical Engineering, Emory University School of
Medicine, Atlanta, GA, United States,
3
Yerkes
National Primate Research, Emory University, GA, United
States
Amygdala-cortical connections consist of major regions
of social brain and mapping such a network may be
critically informative of its roles in autism. In this
study, diffusion tractography was used to delineate the
connections between the amygdala and the prefrontal
areas in macaque monkeys and humans. The results in
monkeys were compared with the tracer literature and
were also compared with those in humans. We found a
generally similar pattern of connections between the
tracer and tractography studies and between two species.
Such work serves as the first step in realistically
mapping amygdala network for the neural underpinnings of
autism.
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