Abstract #0043
Altered choline phospholipid metabolism in pancreatic cancer cells and tumor xenografts
Marie-France Penet* 1 , Tariq Shah* 1 , Santosh Bharti 1 , Yelena Mironchik 1 , Flonn Wildes 1 , Anirban Maitra 2 , and Zaver M. Bhujwalla 1
1
JHU ICMIC Program, Division of Cancer
Imaging Research, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
2
The
University of Texas MD Anderson Cancer Center, Houston,
TX, United States
Pancreatic cancer is an aggressive disease usually
advanced at the time of diagnosis. Biomarkers with
sensitivity and specificity for early diagnosis are
urgently needed. Here we have investigated the
metabolism of a panel of pancreatic cell lines in vitro
and in vivo. Using high-resolution 1H MRS we observed
elevated choline-containing compounds, along with high
levels of choline kinase. Total choline signal was
detected in vivo in tumor xenografts, with the highest
concentration in the Panc1 tumors. Our study showed that
the altered choline phospholipid metabolism could be
used for noninvasive detection of pancreatic cancer and
for treatment strategies.
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