Abstract #0023
MRI Demonstrates a Decrease in Myocardial Infarct Healing and Increase in Compensatory Ventricular Hypertrophy Following Mechanical Microvascular Obstruction
Hisham Z. Bajwa 1 , Lois Do 1 , Mohammed Suhail 1 , Steve W. Hetts 1 , Mark W. Wilson 1 , and Maythem Saeed 1
1
Radiology and Biomedical Imaging, University
of California, San Francisco, San Francisco, California,
United States
Our study was aimed at providing direct evidence that
mechanical obstruction of microvessels in the coronary
vasculature inhibits myocardial infarct resorption and
enhances LV remodeling using MRI and then confirming
these findings with histopathology. We found that
persistent microvascular obstruction after 3 days was
larger on average and more frequently found in animals
that underwent LAD occlusion/microemboli
delivery/reperfusion than animals that were only
subjected to occlusion/reperfusion. The greater
microvascular obstruction in the former was associated
with less infarct resorption, a greater degree of
increase in LV mass and more pronounced decline in LV
ejection fraction.
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