Abstract #0012
Elevated ATP Synthase and Creatine Kinase Activities in Human Visual Cortex during Visual Stimulation: A 31P NMR Magnetization Transfer Study at 7T
Byeong-Yeul Lee 1 , Xiao-Hong Zhu 1 , and Wei Chen 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, Minnesota, United
States
The cerebral ATP synthase (ATPase) and creatine kinase
(CK) reactions are essential in supporting brain energy
and function. In this study, we investigated the central
role of oxidative phosphorylation of ATP in response to
functional visual stimulus in the human visual cortex
using the in vivo 31P MRS with magnetization transfer
technique at 7T; and to further study its temporal
evolution during and after the stimulation. It was found
that both ATPase and CK metabolic fluxes increased
during the visual stimulation. Interestingly, the
elevated ATPase enzyme activity recovered rapidly to the
baseline level after the stimulation; in contrast, a
high CK enzyme activity persisted during the sustained
post-stimulation period, suggesting distinct roles of
ATPase and CK reactions in brain function. More
importantly, the significant increase of ATPase observed
in this study indicates a high demand of oxidative ATP
synthesis/utilization in the activated brain region in
supporting the elevated neuronal activity.
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