Nilesh R. Ghugre1,
2, Venkat Ramanan1, Mihaela Pop1, Jennifer Barry1,
Kim A. Connelly3, Graham A. Wright1, 2
1Physical
Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada; 2Medical
Biophysics, University of Toronto, Toronto, ON, Canada; 3Division
of Cardiology, St. Michaels Hospital, Toronto, ON, Canada
T2 mapping techniques [M=M0.exp(-t/T2)] can detect the occurrence of hemorrhage after acute myocardial infarction but can be confounded by opposing effects from edema. We hypothesized that the M0 term may provide additional information beyond T2 for identifying the hemorrhagic sites. The study involved a porcine model (N=6) with imaging at day 2 post-infarction. Hemorrhagic sites could not be distinctly identified on T2 maps, however M0 maps demonstrated signal voids that were spatially correlated with those identified as hemorrhage on T2* maps. T2 and M0 maps together provide complementary information that may potentially be valuable in simultaneously characterizing both the inflammatory and hemorrhagic state of tissue post-AMI.