Abstract #4514

Changes of Myocardial Lipid Content and Left Ventricular Function in the Course of Acute Hypoglycemia and Inhibition of Lipolysis.

Martin Krssk¹,², Yvonne Winnhofer¹, Peter Wolf¹, Drazenka Jankovic¹, Sabina Baumgartner-Parzer¹, Rodrig Marculescu³, Michael Wolzt⁴, Siegfried Trattnig², Anton Luger¹, Michael Krebs¹

¹Division of Endocrinology and Metabolism, Department of Intrenal Medicine III, Medical University of Vienna, Wien, Austria; ²Centre of Excellence High Field MR, Department of Radiology, Medical University of Vienna, Wien, Austria; ³Department of Laboratory Diagnostics, Medical University of Vienna, Wien, Austria; ⁴Department of Clinical Pharmacology, Medical University of Vienna, Wien, Austria

Proton MRS and MRI were used to follow the myocardial lipid content (MYCL) and left ventricular ejection fraction (LVEF) in the course of acute hypoglycemia and 24h follow up in young healthy male volunteers (n=8). Lipolysis was alternatively inhibited to distinguish the effects of hypoglycemia and counter-regulation induced lipolysis. Acute hypoglycemia did not reduce the LVEF and MYCL, but MYCL decreased in 24h follow up measurement. Inhibition of adipose tissue lipolysis w/o insulin action was accompanied by decrease of MYCL and LVEF. We conclude that MYCL stores play a major role for the maintenance of myocardial function.