Shashank Sathyanarayana
Hegde1, Steven M. Shea, 12, Li Pan, 12,
Parag Karmarkar3, Julien Barbot4, Klaus J. Kirchberg4,
Fijoy Vadakkumpadan5, Jeremy Maurer1, Judy Cook1,
Natalia Trayanova5, Meiyappan Solaiyappan1, Peter V.
Johnston6, Dara L. Kraitchman1
1Radiology,
Johns Hopkins University, Baltimore, MD, United States; 2Center
for Applied Medical Imaging, Siemens Corporation, Corporate Technology,
Baltimore, MD, United States; 3MRI Interventions, Inc., Memphis, Tennesse,
United States; 4Center for Applied Medical Imaging, Siemens
Corporation, Corporate Technology, Princeton, NJ, United States; 5Biomedical
Engineering, Johns Hopkins University, Baltimore, MD, United States; 6Cardiology,
Johns Hopkins University, Baltimore, MD, United States
Catheter-based transendocardial injection offers a minimally invasive method to deliver therapeutics to the heart. MRI-guided delivery of therapeutics at 3T offers the potential for precise targeting of these therapies with superior tissue contrast over conventional X-ray fluoroscopic guidance. We demonstrate here transendocardial injection of a prototype therapeutic into the myocardium of a normal swine using real-time MR guidance and a custom active injection catheter.