Yuegao Huang1,
2, Daniel Coman1, 2, Garry E. Kiefer3,
Sara Samuel4, Fahmeed Hyder1, 4
1Diagnostic
Radiology, Yale University, New Haven, CT, United States; 2Magnetic
Resonance Research Center, Yale University, New Haven, CT, United States; 3Macrocyclics,
Dallas, TX, United States; 4Biomedical Engineering, Yale
University, New Haven, CT, United States
A cocktail of PARACEST agents, each sensitive to an independent parameter, is believed to allow multi-parametric detection. But the multiple-pool proton exchange situation is not a linear combination of two-pool exchange models. To enable multivalent imaging for a cocktail of PARACEST agents, we posited that because PARACEST agents also contain nonexchangeable protons that provide molecular readout with ultrafast chemical shift imaging, as detected by Biosensor Imaging Redundant Deviation in Shifts (BIRDS), the BIRDS properties in a cocktail of PARACEST agents will not be affected, but also enhance precision by adding redundancy for quantifying the CEST contrast.