Lu-Ping Li1,
Jon Thacker2, Tammy Franklin2, Hongyan Du3,
Anindya Sen2, Maria Papadopulou-Rosenzweig4, Richard
Solomon5, Pottumarthi Vara Prasad2
1Radiology,
Northshore University Healthsystem, Evanston, IL , United States; 2Radiology,
Northshore University Healthsystem, Evanston, IL, United States; 3Center
for Clinical & Research Informatics, Northshore University Healthsystem,
Evanston, IL, United States; 4Radiation Medicine, Northshore
University Healthsystem, Evanston, IL, United States; 5Nephrology,
University of Vermont, Burlington,, VT, United States
A prospective, randomized, blinded study was performed to compare the efficacy of two protective interventions (administration of loop diuretic furosemide and antioxidant n-acetyl cysteine (NAC)) in a rat model of contrast-induced nephropathy (CIN). Studies were performed with three different contrast media. Our data with BOLD MRI measurements show that diuretic furosemide resulted in reduced enhancement in R2* post-contrast media while NAC resulted in no appreciable change compared to the control group. Further studies to confirm that the reduced hypoxia leads to reduced CIN with additional direct markers or renal injury are necessary.