Lan Lu1,
Elliott C. Dasenbrook2, David Weaver2, Peter M. Jakob3,
Mitchell L. Drumm2, Michael W. Konstan2, Chris A. Flask1
1Department
of Radiology, Case Western Reserve University, Cleveland, OH, United States; 2Department
of Pediatrics, Case Western Reserve University, Cleveland, OH, United States;
3Department of Physics, University of Wurzburg, Wurzburg, Germany
We have developed a method to normalize lung T1 relaxation time assessments as an biomarker for early-stage lung disease in cystic fibrosis (CF) patients. The T1 relaxation times were normalized by the mean T1 values in the central lung regions to limit the effects of anatomic variation. Normalized T1 assessments were obtained for six CF patients and five healthy controls. The normalized T1 relaxation time assessments showed reduced variation in comparison to conventional T1 relaxation times and differentiated early-stage CF patients from healthy controls while gold-standard pulmonary function tests did not suggesting greater sensitivity of this new MRI method.