Abstract #4041

Environmental Stimulation During Development Modulates Individual Behavioural and Neurochemical Responses to Cannabinoid Agonists in Mice: A 1H MRS Study

Luisa Altabella¹, Chiara Ceci¹, Simone Macri'¹, Rossella Canese², Giovanni Laviola¹

¹Cell Biology and Neuroscience, Istituto Superiore di Sanita', Rome, Italy; ²Cell Biology and Neuroscience, Istituto Superiore di Sanit, Rome, Italy

Adverse environmental conditions may increase the vulnerability towards the effects of the consumption of psychoactive drugs. Conversely, stimulating environmental conditions may exert a protective or compensatory role. Hypothalamic-pituitary-adrenal (HPA) system and the endocannabinoid system (ECS) interact to modulate the expression of emotions. An adolescence treatment in mice with endocannabinoid JWH-018 is studied in adulthood with 1HMRS in combination with a neonatal corticosterone administration (LC) or environmentally enriched (EE) housing after weaning. Major finding indicates that both stresses (LC or EE) can revert the JWH-018 effects in several metabolite concentrations in PFC and Hip.