Andreas Boss1,
Ayse Sila Dokumaci1, Tania Buehler1, 2,
Roland Kreis1, Chris Boesch1
1Depts
Clinical Research and Radiology, University Bern, Bern, Switzerland; 2Institute
of Myology, AIM and CEA, Paris, France
A comprehensive investigation of liver metabolism was performed using a triple tuned 1H/13C/31P-MRS surface coil to assess intrahepatic lipids (1H), glycogen (13C), phosphorous metabolites and the rate constant kPi&[rarr]ATP using saturation transfer (31P). The coil and optimized protocol allowed a full examination in acceptable scan times (~1.5h) without repositioning. In a cross-over design, 6 male subjects were measured before and 3h after intake of either glucose or fructose to test the feasibility of this approach.