Abstract #4005

A Multiparametric MR Approach for Comparative Assessment of Neurometabolites and Brain Microstructural Changes in Mice Model for Cranial and Whole Body Radiation Exposure

Poonam Rana¹, Mamta Gupta¹, Richa Trivedi¹, B.S.Hemanth Kumar¹, Ravi Soni², Ram Kishore Singh Rathore³, Rajendra P. Tripathi¹, Subash Khushu¹

¹NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; ²Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; ³Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh, India

Understanding the early differential response of brain during radiation exposure is significant for better injury management during accidental or intentional exposure to ionizing radiation. The present study based on DTI and 1H MRS was conducted to investigate the early microstructural and metabolic profiles in mouse brain following whole body radiation or cranial radiation exposure. The results exhibited more DTI based FA and MRS based metabolic changes in whole body radiation group compared to cranial irradiation group. This disparity in response could be due to involvement of systemic inflammatory response of central nervous system in case of whole body irradiation only.