Jacob Penner1,
2, Andrew T. Curtis1, 2, Kyle M. Gilbert1,
L. Martyn Klassen1, Joseph S. Gati1, Michael Borrie3,
4, Robert Bartha1, 2
1Centre
for Functional and Metabolic Mapping, Robarts Research Institute, London,
Ontario, Canada; 2Medical Biophysics, Western University, London,
Ontario, Canada; 3Medicine, Western University, London, Ontario,
Canada; 4Division of Aging, Rehabilitation, and Geriatric Care,
Lawson Health Research Institute, London, Ontario, Canada
The purpose of this study was to quantify the metabolite level measurement test/retest reproducibility for a short-echo-time single-voxel 1H semiLASER spectroscopy protocol in human subjects at 7T. MRS data were obtained from the parietal-occipital region of 6 young healthy volunteers (mean age 28.0 2.7 years). The same-day percent differences and the 1-week percent differences were found to range from 3 - 10%. The semiLASER MRS protocol produced high SNR at 7 Tesla and can be used to measure metabolite concentrations with high reproducibility, ideal for measuring metabolic changes in neuropathological conditions.