Peter Adany1,
Phil Lee2, In-Young Choi3
1Hoglund
Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS,
United States; 2Department of Molecular & Integrative
Physiology, Hoglund Brain Imaging Center, University of Kansas Medical
Center, Kansas City, KS, United States; 3Department of Neurology,
Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas
City, KS, United States
An extended non-Fourier based spectral localization technique is proposed for fast and accurate measurements of neurochemicals from non-rectangular, arbitrary shaped brain regions of interest (e.g., gray and white matter) in the human brain in vivo. The proposed spectral localization by imaging (SLIM)-based technique takes into account both inhomogeneous coil sensitivity with the use of multiple-channel receiver coils and B0 inhomogeneity. Thus, full recovery of the MRS signal quality, which is otherwise compromised, is achievable to assess gray and white matter differences of metabolite concentrations with a reduced number of phase-encoding steps and cross-compartmental contamination.