Abstract #3944

Spectrally Interleaved Multi-Echo Sequence for Measurement of Hyperpolarized [1-13C]pyruvate Metabolism

Jae Mo Park¹,², Yi-Fen Yen¹, Priti Balchandani¹,³, Sonal Josan,¹⁴, Ralph Hurd⁵, Dirk Mayer¹,⁴, Daniel Spielman¹,²

¹Radiology, Stanford University, Stanford, CA, United States; ²Electrical Engineering, Stanford University, Stanford, CA, United States; ³Radiology, Mount Sinai School of Medicine, New York, United States; ⁴Neuroscience Program, SRI International, Menlo Park, CA, United States; ⁵Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

We exploit the long T2 of [1-13C]-labeled pyruvate and metabolic products by developing a spectrally interleaved multi-echo sequence using spectral-spatial RF pulses to increase SNR of the labeled metabolites.