Kelvin Billingsley1,
Sonal Josan1, 2, Jae Mo Park1, 3,
Sui Seng Tee1, Yi-Fen Yen1, Ralph Hurd4,
Dirk Mayer1, 2, Daniel Spielman1, 5
1Department
of Radiology, Stanford University, Stanford, CA, United States; 2Neuroscience
Program, SRI International, Menlo Park, CA, United States; 3Department
of Electrical Engineering, Stanford University, Stanford , CA, United States;
4Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United
States; 5Department of Electrical Engineering, Stanford
University, Stanford, CA, United States
This work explores the synthesis, development and application of [1,4-13C]-diethylsuccinate ([13C]-DES) via DNP polarization. These studies provide a reassignment of the metabolites observed in previous reports and a reexamination of the role of the TCA cycle in processing [13C]-labeled diethylsuccinate probes.