Abstract #3928

Using [1-13C]lactic Acid for Hyperpolarized 13C Cardiac Studies

Albert P. Chen¹, Charles H. Cunningham²,³

¹GE Healthcare, Toronto, ON, Canada; ²Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; ³Dept. of Medical Biophysics , University of Toronto, Toronto, ON, Canada

Preparation of hyperpolarized [1-13C]lactate in solution was demonstrated in this study using neat [1-13C]lactic acid as the DNP sample. Hyperpolarized [1-13C]lactate was also compared to [1-13C]pyruvate for in vivo investigation of cardiac PDH flux at the same dose in the same subjects. Hyperpolarized [1-13C]lactate may provide non-invasively assessment of cardiac PDH flux with minimal perturbation of the enzymes involved in this metabolic pathway.