Investigation of Substrate Dose on Rat Cardiac Metabolism in Vivo Using MRS of Hyperpolarized [2-13C]pyruvate

Sonal Josan¹, ², Jae Mo Park², Yi-Fen Yen², Ralph Hurd³, Adolf Pfefferbaum¹, ², Daniel Spielman², Dirk Mayer¹, ²

Hyperpolarized [1-13C]-pyruvate MRS has been used to measure changes in cardiac PDH flux via measurement of 13C-bicarbonate, but may not reflect tricarboxylic acid (TCA) cycle activity.