Abstract #3905

MR Imaging of ex-vivo Mouse Joints on a Clinical 3T System with Diagnostic SPION Imaging Using DUTE in an Arthritis Model.

Lindsey Alexandra Crowe¹, Frank Tobalem², Marije Koenders³, Eline Vermeij³, Fons A. van de Loo³, Azza Gramoun¹, Jatuporn Salaklang⁴, Anthony Redgem⁴, Alke Petri-Fink⁵, Heinrich Hofmann⁶, Wim van der Berg³, Jean-Paul Valle¹

¹Radiology / Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland; ²Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; ³Department of Rheumatology, Rheumatology Research and Advanced Therapeutics,, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; ⁴Adolphe Merkle Institute, Universit de Fribourg, Fribourg, Switzerland; ⁵Adolphe Merkle Institute and Chemistry Departement, Universit de Fribourg, Fribourg, Switzerland; ⁶Institute of Materials, Powder Technology Laboratory, EPFL, Lausanne, Switzerland

Many pre-clinical studies are carried out on clinical MRI systems due to translational possibilities and availability of technology. For small sample sizes, an adapted coil to give high signal intensity is needed. Diagnostic potential of signal loss and positive contrast difference Ultrashort Echo (dUTE) sequences for iron oxide nanoparticle detection (amino-PVA-SPIONs) was compared in a mouse model of antigen induced arthritis. SPION administration routes and doses in arthritic and control knees are compared for synovial uptake with high sample throughput.