Shizhen Chen1,
Yuqi Yang1, Qi Wang1, Haidong Li1, Xin Zhou1
1Wuhan
Center for Magnetic Resonance,Wuhan Institute of Physics and Mathematics,CAS,
Wuhan, Hubei, China
We developed a novel nanosized and pH-trigged biosensor, which encapsulates high-sensitive 19F MRI contrast agent in gold nanoparticles (AuNPs)-capped mesoporous silica nanoparticles (MSNs) platform,and this biosensor is capable to specifically target to lung cancer cell (A549) for intracellular MRI.