Abstract #3892

A R2p/R1p Ratiometric Approach with Gd Containing Liposomes for the Imaging of Matrix Metalloproteinases by MRI

Giuseppe Digilio¹, Valeria Catanzaro², Valeria Menchise³, Sergio Padovan³, Martina Capozza⁴, Linda Chaabane⁵, Silvio Aime⁴

¹Universit del Piemonte Orientale "A. Avogadro", Alessandria, AL, Italy; ²Istituto di Ricerca Diagnostica e Nucleare SDN, Via Gianturco 113, Napoli, 80143, Na, Italy; ³CNR - IBB, Torino, TO, Italy; ⁴Department of Chemisty & Center for Molecular Imaging,, University of Turin, Torino, TO, Italy; ⁵Institute for Experimental Neurology - INSpe, San Raffaele Scientific Institute, Milano, MI, Italy

A novel paramagnetic Gd-loaded liposome for the MRI assessment of the activity of Matrix Metalloproteinase-2 is described. It relies on a ratiometric R2p/R1p procedure that is independent of the total concentration of gadolinium.