Yuegao Huang1,
2, Daniel Coman1, 2, Garry E. Kiefer3,
Fahmeed Hyder1, 4
1Diagnostic
Radiology, Yale University, New Haven, CT, United States; 2Magnetic
Resonance Research Center, Yale University, New Haven, CT, United States; 3Macrocyclics,
Dallas, TX, United States; 4Biomedical Engineering, Yale
University, New Haven, CT, United States
Temperature mapping has important biomedical applications. Unlike PARACEST agents that provide temperature contrast, the Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) method provides absolute temperature mapping, where directly imaging proton resonances of the lanthanide complexes with 3D CSI is key. Motivated by success of TmDOTMA- with BIRDS for temperature mapping, we designed new agents with methyl groups on different positions of DOTA-based chelates. Comparison with TmDOTMA- shows much higher temperature sensitivities with BIRDS are achieved with the new agents. Moreover, the new agents have strong PARACEST capabilities to allow quantitative molecular imaging by combining with BIRDS.