Labeling of Macrophages with Novel Gadolinium Oxide Nanoparticles for in vivo Imaging of Inflammation

Gary R. Stinnett¹, Minjung Cho², Huigang Zhu², Pedersen E. Steen¹, Christeen Beeton¹, Vicki L. Colvin², Robia G. Pautler¹

We have developed novel gadolinium oxide contrast agents with an R1 three times higher than Magnevist in a 9.4 T MRI. These agents were used to label macrophages resulting in labeled cells significantly brighter than non-labeled cells.