Holly Elizabeth Holmes1,
Nick M. Powell*1, 2, Jack A. Wells1, Niall
Colgan1, James M. O'Callaghan1, Da Ma1,
2, Marc Modat2, Manuel Jorge Cardoso2, Simon
Richardson1, Bernard M. Siow1, Michael J. O'Neill3,
E Catherine Collins4, Elizabeth Fisher5, Sebastien
Ourselin2, Mark F. Lythgoe1
1Centre
for Advanced Biomedical Imaging, University College London, London, Greater
London, United Kingdom; 2Centre for Medical Image Computing,
University College London, London, Greater London, United Kingdom; 3Eli
Lilly & Co. Ltd, Windlesham, Surrey, United Kingdom; 4Eli
Lilly & Co. Ltd, Indianapolis, IN, United States; 5Institute
of Neurology, University College London, London, Greater London, United
Kingdom
Preclinical MRI has become a promising technique to examine mouse brain morphology. In this study, we employed an optimised sequence for high resolution 3D in vivo imaging. We used a novel automatic image analysis toolbox to examine a mouse model of Alzheimers disease (rTg4510). Tensor-based morphometry analysis revealed significant changes in local brain volume between this model and age-matched wild-types. Our findings correspond to expected changes, including hippocampal and forebrain atrophy, as well as ventricular dilation.