Ulrich Pilatus1,
Oliver Br2, Johannes Rieger2, Stefanie Pellikan1,
Maurice Harth1, Joachim Steinbach2, Elke Hattingen1
1Institute
of Neuroradiology, Goethe-University Frankfurt, Frankfurt, Germany; 2Dr.
Senckenbergisches Institut fr Neuroonkologie, Goethe-University Frankfurt,
Frankfurt, Germany
31P and 1H MRSI was used to monitor changes in phospholipid and energy metabolism in recurrent gliomas during antiangiogenic therapy. Elevated PEth/GPE ratios were typical for all recurrent gliomas while high PCho/GPC ratios correlated with the survival time. Both anabolite/katabolite ratios decreased upon onset of therapy. Energy metabolism, mesures as PCr/Pi ratio, was deprived in tumor tissue.