Jing Zhang1,
Alex L. MacKay1, 2
1Department
of Radiology, University of British Columbia, Vancouver, British Columbia,
Canada; 2Department of Physics and Astonomy, University of British
Columbia, Vancouver, British Columbia, Canada
2. Myelin water fractions (MWF) estimated by mcDESPOT method are significantly higher than MWF values derived from multi-spin echo T2-decay curve approachs. It has been suggested that magnetization transfer (MT) may influence the MWF maps. We performed the mcDESPOT method with both short and longer RF pulses in order to investigate effect of MT on the MWF maps. We conclude that the MT effects did play a role in the estimated MWF from mcDESPOT. This effect was more marked in grey matter but less marked in white matter.