Tracy L. Luks1,
Yan Li1, Angela Jakary1, Erin Gillung2,
Natalie M. Holbrook2, Stuart Eisendrath2, Pratik
Mukherjee1, Sarah J. Nelson3
1Department
of Radiology and Biomedical Imaging, University of California San Francisco,
San Francisco, CA, United States; 2Langley Porter Psychiatric
Institute, San Francisco, CA, United States; 3Department of
Bioengineering and Therapeutic Sciences, University of California San
Francisco, San Francisco, CA, United States
We used 7T MRI gradient-echo imaging to examine the thickness of 2 regions within hippocampal CA1, the cell-body layer stratum pyramidale (SP) and the synaptic layer stratum radiatum/stratum lacunosum-moleculare (SRLM) in Major Depressive Disorder patients, and to test the hypothesis that decreases in these ultra-high field MRI measures of hippocampal thickness would be significantly associated with increases in clinical symptom severity and deficits in memory and attention neurocognitive measures known to involve hippocampal function.