Yan Li1, Angela
Jakary1, Erin Gillung2, Natalie M. Holbrook2,
Stuart Eisendrath, 23, Sarah J. Nelson1, 4,
Pratik Mukherjee1, Tracy L. Luks1
1Department
of Radiology and Biomedical Imaging, University of California, San Francisco,
CA, United States; 2Langley Porter Psychiatric Institute, University
of California, San Francisco, CA, United States; 3Department of
Psychiatry, University of California, San Francisco, CA, United States; 4Department
of Bioengineering and therapeutic sciences, University of California, San
Francisco, CA, United States
The purpose of this study was to compare relative metabolite levels between unmedicated patients with MDD and healthy controls in the anterior cingulate cortex (ACC) and anterior/mediodorsal thalamus (Thal) using 3D short-echo MRSI at 7 Tesla. Compared to controls, patients had significantly decreased levels of GABA/tCr and NAA/tCr in a subregion of the left ACC, significantly elevated tCho/tCr and lower Glu/tCr in the right mediodorsal thalamus, and lower mI/tCr bilaterally in the anterior and mediodorsal thalamus.