Abstract #3587

Supertoroidal Analysis of Diffusion Tensor MRI of Patients with First-Episode Psychosis

Fabricio R. S. Pereira¹, Marcus V. Zanetti¹, Maurcio H. Serpa¹, Tiffany Moukbel Chaim¹, Geraldo Busatto¹, Choukri Mekkaoui², Marcel Parolin Jackowski³

¹School of Medicine, University of So Paulo, So Paulo, Brazil; ²Harvard Medical School, Boston, MA, United States; ³Computer Science, University of So Paulo, So Paulo, Brazil

Diffusion Tensor MRI provides the fractional anisotropy (FA) and mean diffusivity (MD) indices to characterize the axonal integrity and structure of white matter. Although abnormal levels of FA and MD have been associated with neuropsychiatric conditions, these indices showed to be insufficient to link brain abnormalities to their corresponding clinical symptoms. In this work, we assess the supertoroidal representation of the diffusion tensor by comparing the toroidal volume and toroidal curvature indices to MD and FA in treatment-nave patients with first-episode psychosis versus healthy controls. TV and TC showed similar findings to MD and FA, but circumscribed to specific areas.