Minhui Ouyang1,
Uma Rao2, Tejasvi Gundapuneedi1, Hao Huang1
1Advanced
Imaging Research Center, University of Texas Southwestern Medical Center,
Dallas, TX, United States; 2Department of Psychiatry and
Behavioral Sciences, Meharry Medical College, Nashville, TN, United States
The underlying mechanisms of long-lasting impairments in behavioral, cognitive and social functioning caused by childhood maltreatment (MALTX) are not well-understood. Integrating functional and structural connectivity from resting state fMRI (rs-fMRI) and DTI provides insight of the affected brain circuits including both cortical region and white matter tracts in the maltreated subjects. In this study, rs-fMRI and DTI scanning were acquired from 19 MALTX adolescent volunteers and 13 age-matched control volunteers. We have identified disrupted structural and functional connectivity and revealed the relationship of the abnormal connectivity of both types in the maltreated healthy subjects.