Abstract #3561

Neuroimaging Biomarkers of Mild Traumatic Brain Injury (MTBI) and Its Recovery: A Preliminary Study in Acute Setting

Jie Yang¹, Zhifeng Kou^1,2, Robert Dean Welch³, Randall Benson⁴, Ramtilak Gattu², Valerie Mika³, Ewart Mark Haacke¹

¹Radiology, Wayne State University School of Medicine, Detroit, MI, United States; ²Biomedical Engineering, Wayne State University, Detroit, MI, United States; ³Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, United States; ⁴Center for Nerologic Studies, Novi, MI, United States

Using SWI and resting-state fcMRI methods, this study aims to provide neuroimaging biomarkers that may reveal neurovascular deficits and changes in function connectivity of patients post traumatic brain injury at the acute stage. Subtle medullary vein damage seen by SWI and disrupted resting-state networks indicated by fcMRI, together with the changes in these MRI indices over time will be imaging biomarkers complimentary to routine clinical evaluation of mTBI patients.