Altered Spontaneous Neural Activity in Large-Scale Brain Systems Associated with Executive Dysfunction in Attention Deficit Hyperactivity Disorder

Fei Li¹, Ning He², Yuanyuan Li², Xiaoqi Huang¹, Su Lui¹, Lanting Guo², Qiyong Gong¹

Present study evaluates the relationship between altered spontaneous brain activity and functional connectivity and executive dysfunction in ADHD. In accord with the revised model of ADHD pathopsysiology, the present findings indicate intrinsic brain activity altered not only in fronto-striatal circuit dominantly with regional deficit and excess, but also accompany with increased fronto-striatal FC and decreased fronto-parieto-temporal and fronto-cerebellar FC within different large-scale resting-state networks in ADHD. Furthermore, the altered FC associated with performance in WCST and Stroop test show the linkage between executive dysfunction and ADHD tentatively established by not only fronto-striatal hypothesis also dysfunction in fronto-parietal networks.