Abstract #3497

Robust Image Registration for In-Vivo Human Osteoarthritic Knees and Cartilage Specimens and Correlation Between In-Vivo and Ex-Vivo T1&[rho]

Wei-Ching Lo¹, Karupppasamy Subburaj¹, Lorenzo Nardo¹, Sharmila Majumdar¹, Michael Ries², Xiaojuan Li¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; ²Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United States

Along with the efforts of developing prevention strategies and new treatment methods for osteoarthritis, there are increasing demands for early diagnosis and critical treatment monitoring of cartilage degeneration in osteoarthritis. As a non-invasive imaging technique, it would be critical to link the biochemical analysis with in vivo imaging measures. This study developed a robust registration algorithm for in vivo and ex vivo cartilage imaging to explore the link between imaging measures and biochemical analysis.