Abstract #3406

Multiparametric MRI Discriminates Between Benignity and Insignificant and Significant Cancers in MRI-Ultrasound Fusion Targeted Biopsy

Daniel J.A. Margolis¹, Edward Chang², Frederick Dorey³, Jiaoti Huang⁴, Maria Luz Macairan², Shyam Natarajan⁵, Steven Raman¹, Geoff Sonn², Leonard Marks²

¹Radiological Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA, United States; ²Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States; ³Department of Pediatrics, USC Keck School of Medicine, Los Angeles, CA, United States; ⁴Pathology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States; ⁵Bioengineering, UCLA David Geffen School of Medicine, Los Angeles, CA, United States

The components of multiparametric MRI, including overall suspicion, are evaluated as predictors of the presence of any cancer and significant (Gleason pattern 4) cancer in MRI-ultrasound fusion targeted biopsies. Clinical parameters and standardized scoring of T2 appearance, dynamic contrast enhancement, and overall suspicion on a 1-5 ranked scale after published recommendations, and the quantitative apparent diffusion coefficient (ADC), were compared with the highest Gleason score in biopsy targets. All parameters were predictive of any cancer and, especially, significant cancer, with almost no significant cancer in low (score 1-2) suspicion targets. All except ADC could significantly discriminate Gleason grades in targets.