Maysam Jafar1,
Veronica A. Morgan2, Sharon L. Giles2, Catherine J.
Simpkin2, Rosalind Eeles3, Elizabeth Bancroft3,
Elena Castro3, Nandita M. deSouza4
1Cancer
Research UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research,
Sutton, Surrey, United Kingdom; 2Cancer Research UK and EPSRC
Cancer Imaging Centre, Royal Marsden NHS Foundation Trust, Sutton, Surrey,
United Kingdom; 3Genetics & Epidemiology, Institute of Cancer
Research, Sutton, Surrey, United Kingdom; 4Cancer Research UK and
EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden
NHS Foundation Trust, Sutton, Surrey, United Kingdom
Diffusion-weighted MRI has increased sensitivity for detecting small prostate cancers when used in conjunction with T2W imaging. This prospective study examines its sensitivity and specificity for detecting tumors in patients with a high-risk (significant family history) of prostate cancer using either qualitative (observer assessed) or quantitative (histogram) analysis. Qualitative analysis had a 77% sensitivity 92% specificity for tumor detection on a per patient basis; ROC curves of 10th and 25th centiles derived from histogram analyses indicated that for a specificity of 90%, sensitivity of these centiles was <25% for detecting tumor in central gland and peripheral zone of the prostate.