Mami Iima1,
Masako Kataoka1, Denis Le Bihan2, Masaki Umehana3,
Takuma Imakita3, Masayuki Nakagawa1, Shotaro Kanao1,
Kojiro Yano1, 4, Thorsten Feiweier5, Kaori
Togashi1
1Diagnostic
Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine,
Kyoto, Japan; 2Neurospin, CEA
Saclay, Gif-sur-Yvette,
Ile-de-France, France; 3Kyoto University Faculty of
Medicine, Kyoto, Japan; 4Information Science and Technology, Osaka
Institute of Technology, Hirakata, Osaka, Japan; 5Siemens AG,
Erlangen, Germany
We performed IVIM MRI in 23 patients with benign and malignant breast lesions. The flowing blood fraction, fivim was significantly (p= 0.01) higher in malignant tumors compared in normal breast, and fivim for malignant tumors showed weak negative correlation with pseudo-diffusion, D*, with a Pearsonfs coefficient (r) of -0.42. There was no significant difference in D* across malignant, benign tumor and normal breast tissue. However, the ADC in malignant tumors was significantly lower than that of benign tumor and normal breast tissue IVIM maps clearly reflected tumor perfusion characteristics, in agreement with Contrast-Enhanced images. These results suggest that images of blood microvasculature can be obtained without contrast agents using IVIM MRI, of high interest for patients with renal failure.