Abstract #3250

On the Spatial Distribution of Cerebrovascular Reactivity During Breath Hold and CO2 Inhalation Tasks as Assessed by Data-Driven Analysis Methods

Ekaterina Tchistiakova¹,², David E. Crane³, Jeremy Gilbert⁴, Sandra E. Black³,⁵, Bradley J. MacIntosh¹,³

¹Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; ²Heart and Stroke Foundation Centre for Stroke Recovery,, Sunnybrook Research Institute, Toronto, Ontario, Canada; ³Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Research Institute, Toronto, Ontario, Canada; ⁴Department of Medicine, Division of Endocrinology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; ⁵Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada

Cerebrovascular reactivity (CVR) can provide valuable information on hymodynamic impairment in a wide range of neurological conditions. In this study we compared the spatial distribution of CVR maps obtained using CO₂ inhalation and breath hold (BH) tasks. The two hypercapnic challenges showed a good spatial overlap of CVR maps. Discrepancies were confined to inferior temporal and frontal pole regions with higher sensitivity during BH and CO₂ respectively. CO₂ CVR presented with increase in regions related to visual processing and sensorimotor areas compared to BH.