Hye-Young Heo1,
2, Casey P. Johnson1, Daniel R. Thedens1, John A.
Wemmie3, 4, Vincent A. Magnotta1, 5
1Department
of Radiology, University of Iowa, Iowa City, IA, United States; 2Department
of Biomedical Engineering, University of Iowa, Iowa City, IA, United States; 3Department
of Psychiatry, University of Iowa, Iowa City, IA, United States; 4Department
of Neurosurgery, University of Iowa, Iowa City, IA, United States; 5Department
of Psychiatry, University of Iowa , Iowa City, IA, United States
The purpose of this study is to assess the temporal dynamics of BOLD, ASL, and T1ρ using phase-encoded visual stimulation. Phase-encoded activation maps were calculated from the measurements obtained using an expanding ring stimulus that induce traveling waves of neural activity in the visual cortex. The results show that pH-sensitive T1ρincreased slightly first, followed by ASL and BOLD signal in the primary visual cortex, V1. This study support that local acidosis induced by the neural activity might be a principle factor in neurovascular coupling.