Prasanth K. Chelikani1,
Ursula I. Tuor2, David K. Min1
1Gastrointestinal
Research Group, Production Animal Health, Faculty of Veterinary Medicine,
University of Calgary, Calgary, Alberta, Canada; 2Clinical
Neurosciences, Radiology, and Physiology and Pharmacology, Hotchkiss Brain
Institute, University of Calgary, Calgary, Alberta, Canada
The gut hormone Glucagon-like peptide-1 (GLP-1) plays an important role in the regulation of food intake and body weight. However, less is known of the central mechanisms that are engaged by GLP-1 to regulate energy balance. We provide evidence in a novel rat model that IV infusion of an anorexic dose of GLP-1 increases BOLD fMRI activity in homeostatic regions such as the hypothalamus and nucleus tractus solitarius, as well as non-homeostatic regions such as the hippocampus.